METABOLIC PRODUCTS OF MICROORGANISMS 116

Photosynthetic Microorganisms and Valuable Products

Natural Products from Marine Microorganisms

Metabolic products of microorganisms. 254. Structure of the new nikkomycins pseudo-Z and pseudo-J.

Two new nikkomycins were isolated from the fermentation broth of Streptomyces tendae Tü 901/PF 53+-3. These new metabolites, nikkomycins pseudo-Z (psi-Z,1) and pseudo-J (psi-J, 2) differ from the corresponding nikkomycins Z and J by a C-glycosidic bond between C-5 of uracil and C-1' of 5-amino-5-deoxy-D-allo-furanuronic acid instead of an N-glycosidic bond. The structure elucidation was achieve...

Metabolic products of microorganisms 142. A new antibiotic derinamycin, inhibitor of DNA and RNA synthesis.

Derinamycin was isolated from the myecelium of Streptomyces venezuelae Tü 1102 and its molecular formula was tentatively assigned as C51H93NO23. The antibiotic inhibits the growth of fungi, gram-positive bacteria and certain gram-negative bacteria but is less acitve against yeasts. A study of derinamycin action on the macromolecular synthesis of intact Bacillus subtilis revealed that the anti...

Metabolic products of microorganisms. 196 The structure of ethericin B, a new diphenylether antibiotic.

Ethericin B(Ia) was isolated together with ethericin A1) from fermentations of Aspergillus funiculosus Tü 680. The structure of ethericin B was established as 4-carbethoxy-5,5'-dihydro-xy-3,3'-dimethyl-diphenyl ether by chemical degradation, mass spectrometry, 1H-NMR and comparison with synthetic 4-carbethoxy-5,5'-dimethoxy-3,3'-dimethyl-diphenyl ether.